0323 Natural Evolution of Insomnia in Major Depressive Disorders

Abstract Introduction Insomnia is a fairly common sleep disturbance affecting nearly one third of the general population. Although its predictive value for major depressive disorder (MDD) has been well documented, little known about role in appearance first episode or recurrence. In this study, we examine insomnia symptoms incidence and recurrence MDD. Methods longitudinal 2 interview waves were conducted between 2002 2015. The initial interviews (wave 1 [W1]) carried out with 12,218 individuals aged ≥18 years from population 8 US states. At follow-up 3 later [W2]), 10,931 participants agreed to be interviewed again. Data analyzed who participated both (N=10,931). A diagnosis MDD was made according Diagnostic Statistical Manual Mental Disorders, Fifth Edition (DSM-5) criteria. defined DSM-5 criteria A, C, D disorder. Results 12-month prevalence 9.5% (95% CI, 9.0%-10.0%) 12.1% 11.5%-12.7%) W1 W2, respectively. Over course 2.6% experienced depression 2.3%-2.9%). After adjusting age, gender, race, body mass index, participant characteristics that predicted recurrent W2 included early morning awakenings (EMA) (relative risk [RR], 3.2; 95% 2.3-4.4), being dissatisfied one’s (RR, 2.8; 2.1-3.7), nocturnal 2.4; 1.8-3.2), difficulty initiating (DIS) 2.0; 1.5-2.9). by DIS 3.8; 2.5-5.9), 2.1; 1,4-3.2), EMA 1.2-3,2) at W1. Conclusion appear play an important part predicting development as depression. Support (if any) analysis study funded Takeda Pharmaceutical Company.